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Reply With QuoteThey need to add "killer withdrawal" to the list of negative side effects. Morphine withdrawal had nothing on Cymbalta withdrawal.... that was just plain miserable!
This is a discussion on FDA Panel to Consider Pain Indication for Antidepressant (Cymbalta) within the Pain Management forums, part of the General Spine Discussion Forums category; WASHINGTON (MedPage Today) -- An FDA advisory committee will meet later this week to review whether the antidepressant duloxetine (Cymbalta) ...
FDA Panel to Consider Pain Indication for Antidepressant (Cymbalta) WASHINGTON (MedPage Today) -- An FDA advisory committee will meet later this week to review whether the antidepressant duloxetine (Cymbalta) should be used as a treatment for chronic pain despite risks that include liver damage and skin disease...
FDA Panel to Consider Pain Indication for Antidepressant (click here for the full article at MedPage Today)
Justin Averna
Founder & President, Spine Patient Society™
www.SpinePatientSociety.org
A 501(c)(3) Tax-Exempt Nonprofit & Charitable Organization
I'm here to help.
- 1994: Football Injury, Severe Hyperextension
- 1997: Snow Skiing Injury
- 3/7/1997, 17 years old: Laminotomy L4/L5
- 1999 & 2003: Motor Vehicle Accidents (not at fault both times) --> Grade V Annular Tears L4/L5 & L5/L6
- 11/15/2003, 23 years old: 2-Level ProDisc® L4/L5 & L5/L6*, *lumbosacral transitional vertebra --> Dr. Rudolf Bertagnoli
- 4/2008: 4.5 years pain-free before "new" leg pain
- 5/14/2009, 29 years old: Dynamic Stabilization System L4/L5, Dr. Rudolf Bertagnoli
Questions? Suggestions? Need help with registering, creating a signature, etc.?
justin (at) spinepatientsociety.org
Disclosure: I have no financial relationships with any surgeons, spine clinics, device manufacturers, pharmaceutical companies, hospitals, etc. -- the SPS Board of Directors serve without compensation.
re: FDA Panel to Consider Pain Indication for Antidepressant (Cymbalta) They need to add "killer withdrawal" to the list of negative side effects. Morphine withdrawal had nothing on Cymbalta withdrawal.... that was just plain miserable!
31 years old-
1/06- In wreck with 18 wheeler at 25 years old; 6/06- Head on collision on Interstate, both wrecks other drivers fault. Numerous MRI's, PT, chiropractic, acupuncture, TENS therapy, massage therapy, facet injections, epidural injections, Nerve study, Discogram, confirms pain in L4/5, IDET, decompression, Bi-lateral neurotomy L3/4/5, denied by insurance twice, in Active L clinical trial, had surgery March 17, 2009 in Miami, FL- received Active L disc at 29 years old. Pain and medication free as of October 2010!
Mommy to Emma- 8 years, Ava- 5.5 years & had baby Eli after ADR, via c-section on March 25, 2011, completely pain free still!
Re: FDA Panel to Consider Pain Indication for Antidepressant (Cymbalta) Wow, didn 't even know they were "considering" it. I've been on Cymbalta for depression and joint pain for 2 years now. I agree with KBear about withdrawal symptoms....if I only miss 2 days, I have horrible headaches, light sensitivity, and mood is terrible....
~When you're feeling your worst, that's when you get to know yourself the best~
37 Year old female with mechanical neck arthritis
- C4-5 Mild disc bulge
- C5-6 Ruptured disc with spinal cord compression
- C8 Bone spur
- Cervical Artificial Disc Replacement ProDisc-C Surgery August 2010
Re: FDA Panel to Consider Pain Indication for Antidepressant (Cymbalta) I was going to start cymbalta on monday, not anymore.Originally Posted by KBear
C4-5: Mild disc height loss with central annular fissure. Small broad-based left paracentral disc protrusion. Moderate central canal stenosis-the disc protrusion abuts and mildly flattens the left ventral surface of the spinal canal.
C5-6: Disc desiccation with mild height loss.Diffuse discosteophyte bulge anduncovertebral joint hypertrophy, moderate central canal stenosis- Severe neuroforaminal stenosis bilaterally, right greater than left
Re: FDA Panel to Consider Pain Indication for Antidepressant (Cymbalta) Cymbalta is a great medication. I wouldn't let one online post sway you from medical treatment that might ultimately benefit you. Cymbalta has been used "off-label" for pain, but now it has FDA approval to treat pain (it was originally approved as an antidepressant and also for postherpetic neuraglia).
Justin Averna
Founder & President, Spine Patient Society™
www.SpinePatientSociety.org
A 501(c)(3) Tax-Exempt Nonprofit & Charitable Organization
I'm here to help.
- 1994: Football Injury, Severe Hyperextension
- 1997: Snow Skiing Injury
- 3/7/1997, 17 years old: Laminotomy L4/L5
- 1999 & 2003: Motor Vehicle Accidents (not at fault both times) --> Grade V Annular Tears L4/L5 & L5/L6
- 11/15/2003, 23 years old: 2-Level ProDisc® L4/L5 & L5/L6*, *lumbosacral transitional vertebra --> Dr. Rudolf Bertagnoli
- 4/2008: 4.5 years pain-free before "new" leg pain
- 5/14/2009, 29 years old: Dynamic Stabilization System L4/L5, Dr. Rudolf Bertagnoli
Questions? Suggestions? Need help with registering, creating a signature, etc.?
justin (at) spinepatientsociety.org
Disclosure: I have no financial relationships with any surgeons, spine clinics, device manufacturers, pharmaceutical companies, hospitals, etc. -- the SPS Board of Directors serve without compensation.
Re: FDA Panel to Consider Pain Indication for Antidepressant (Cymbalta) I wouldn't not take it because of withdrawal, it was a lifesaver for me. I would still be taking it, if it was safe while pregnant. It helped tremendously with my pain and I would take it again, even knowing what I know now.
31 years old-
1/06- In wreck with 18 wheeler at 25 years old; 6/06- Head on collision on Interstate, both wrecks other drivers fault. Numerous MRI's, PT, chiropractic, acupuncture, TENS therapy, massage therapy, facet injections, epidural injections, Nerve study, Discogram, confirms pain in L4/5, IDET, decompression, Bi-lateral neurotomy L3/4/5, denied by insurance twice, in Active L clinical trial, had surgery March 17, 2009 in Miami, FL- received Active L disc at 29 years old. Pain and medication free as of October 2010!
Mommy to Emma- 8 years, Ava- 5.5 years & had baby Eli after ADR, via c-section on March 25, 2011
Re: FDA Panel to Consider Pain Indication for Antidepressant (Cymbalta) It has been the best antidepressant medicine that I've been on. Withdrawal symptoms are something that comes with almost any meds you are taking. This article was just something completely new to me. If you are weaned of the Cymbalta under dr supervision, it shouldn't be as bad.
Re: FDA Panel to Consider Pain Indication for Antidepressant (Cymbalta) Agreed, I did mine on my own, telling the dr as I cut my dose, and ended up weaning way too fastly (which caused more withdrawal symptoms). When I was on the Cymbalta, I was able to get off all other narcotics and medications! When I quit Cymbalta is when I had to start taking Vicodin again. I also was on a really high dose, 2 of the 60mg pills a day.
31 years old-
1/06- In wreck with 18 wheeler at 25 years old; 6/06- Head on collision on Interstate, both wrecks other drivers fault. Numerous MRI's, PT, chiropractic, acupuncture, TENS therapy, massage therapy, facet injections, epidural injections, Nerve study, Discogram, confirms pain in L4/5, IDET, decompression, Bi-lateral neurotomy L3/4/5, denied by insurance twice, in Active L clinical trial, had surgery March 17, 2009 in Miami, FL- received Active L disc at 29 years old. Pain and medication free as of October 2010!
Mommy to Emma- 8 years, Ava- 5.5 years & had baby Eli after ADR, via c-section on March 25, 2011
Re: FDA Panel to Consider Pain Indication for Antidepressant (Cymbalta) I'm just very surprised that FDA is only now considering it for pain relief...I was prescriberd Cymbalta in combination as an antidepressant and joint pain (before we realized that my joint pain was the cdulprit of my joint pain) and it has worked really well. Now I understand why some doctor's told me that Cymbalta is not for pain when I told them I was prescribed that medication for both symptoms.
~When you're feeling your worst, that's when you get to know yourself the best~
37 Year old female with mechanical neck arthritis
- C4-5 Mild disc bulge
- C5-6 Ruptured disc with spinal cord compression
- C8 Bone spur
- Cervical Artificial Disc Replacement ProDisc-C Surgery August 2010
Re: FDA Panel to Consider Pain Indication for Antidepressant (Cymbalta) Considering it has been used "off label" for some time, I would think some of the other, less expensive seritonin-norepinephrine re-uptake inhibitors that are not still under patent would be effective as well. No drug company is going to go to the expense of pushing a drug through the FDA unless they still have a patent.
Another thing, Cymbalta doesn't have introductory doses like some others to help overcome the initial break-in period of side effects. I know one doc who had people open the capsule, pore the granules onto a dish, wet the tip of their finger and role it through the granules. This gets approximately 1/3 to 1/2 the dose. Take this dose instead of the full capsule for several days to minimize start up side effects. As usual, ask your doctor before trying this.
Low back pain became somewhat dehabilitating in 2005
Have had 11 steroid injections, IDET, Trial for nerve stimulator, PT, chiropractic trial, practically every med known to mankind. Discogram indicated three diseased levels with L5-S1 being the most likely pain generator. Post minimally invasive PLIF with internal fixation (titanium) on 12-28-09 of L5-S1. Doing better than expected. Last opioid 7/9/10. Five months pain free, then my neck turned against me. MRI on 12/1/10-- disease at C2 to C7. Only surgical alternative is to fuse entire C-spine. Diagnosed now with Aggressive Relapsing-Remitting Multiple Sclerosis with cord & brainstem active lesions
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