I Attended a CME conference where the use of Tylenol 3000 mg to 4000 mg a day in divided doses in now the first line of approach for osteoarthritis. Needs to be taken regularly for 2 weeks to see what the effect is going to be. I have always been a little bit hesitant about above 3,000 mg myself. At this level, it leaves a bit of room for other combo drugs like Darvocet, Vicodin and the like.

I am going to up my tylenol dose instead of using it just when something hurts.